Glypican-3 targeted delivery of (89)Zr and (90)Y as a theranostic radionuclide platform for hepatocellular carcinoma

Glypican-3 (GPC3) is a tumor associated antigen expressed by hepatocellular carcinoma (HCC) cells. This preclinical study evaluated the efficacy of a theranostic platform using a GPC3-targeting antibody αGPC3 conjugated to zirconium-89 ((89)Zr) and yttrium-90 ((90)Y) to identify, treat, and assess t...

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Detalles Bibliográficos
Autores principales: Labadie, Kevin P., Ludwig, Andrew D., Lehnert, Adrienne L., Hamlin, Donald K., Kenoyer, Aimee L., Sullivan, Kevin M., Daniel, Sara K., Mihailovic, Tara N., Sham, Jonathan G., Orozco, Johnnie J., Yeung, Raymond S., Chen, Delphine L., Wilbur, D. Scott, Miyaoka, Robert S., Park, James O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881163/
https://www.ncbi.nlm.nih.gov/pubmed/33580090
http://dx.doi.org/10.1038/s41598-021-82172-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881163/
https://www.ncbi.nlm.nih.gov/pubmed/33580090
http://dx.doi.org/10.1038/s41598-021-82172-w

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