A homology independent sequence replacement strategy in human cells using a CRISPR nuclease

Precision genomic alterations largely rely on homology directed repair (HDR), but targeting without homology using the non-homologous end-joining (NHEJ) pathway has gained attention as a promising alternative. Previous studies demonstrated precise insertions formed by the ligation of donor DNA into...

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Detalles Bibliográficos
Autores principales: Danner, Eric, Lebedin, Mikhail, de la Rosa, Kathrin, Kühn, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881171/
https://www.ncbi.nlm.nih.gov/pubmed/33499763
http://dx.doi.org/10.1098/rsob.200283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881171/
https://www.ncbi.nlm.nih.gov/pubmed/33499763
http://dx.doi.org/10.1098/rsob.200283

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