Amphidinol 3 preferentially binds to cholesterol in disordered domains and disrupts membrane phase separation

Amphidinol 3 (AM3), a polyhydroxy-polyene metabolite from the dinoflagellate Amphidinium klebsii, possesses potent antifungal activity. AM3 is known to interact directly with membrane sterols and permeabilize membranes by forming pores. Because AM3 binds to sterols such as cholesterol and ergosterol...

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Detalles Bibliográficos
Autores principales: Hieda, Manami, Sorada, Akira, Kinoshita, Masanao, Matsumori, Nobuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881217/
https://www.ncbi.nlm.nih.gov/pubmed/33614998
http://dx.doi.org/10.1016/j.bbrep.2021.100941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881217/
https://www.ncbi.nlm.nih.gov/pubmed/33614998
http://dx.doi.org/10.1016/j.bbrep.2021.100941

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