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Amphidinol 3 preferentially binds to cholesterol in disordered domains and disrupts membrane phase separation
Amphidinol 3 (AM3), a polyhydroxy-polyene metabolite from the dinoflagellate Amphidinium klebsii, possesses potent antifungal activity. AM3 is known to interact directly with membrane sterols and permeabilize membranes by forming pores. Because AM3 binds to sterols such as cholesterol and ergosterol...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881217/ https://www.ncbi.nlm.nih.gov/pubmed/33614998 http://dx.doi.org/10.1016/j.bbrep.2021.100941 |