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Dissecting the impact of target-binding kinetics of protein binders on tumor localization
Systematic control of in vivo behavior of protein-based therapeutics is considered highly desirable for improving their clinical outcomes. Modulation of biochemical properties including molecular weight, surface charge, and binding affinity has thus been suggested to enhance their therapeutic effect...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881221/ https://www.ncbi.nlm.nih.gov/pubmed/33615202 http://dx.doi.org/10.1016/j.isci.2021.102104 |