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The IL-27 receptor regulates TIGIT on memory CD4(+) T cells during sepsis

Sepsis is a leading cause of morbidity and mortality associated with significant impairment in memory T cells. These changes include the upregulation of co-inhibitory markers, a decrease in functionality, and an increase in apoptosis. Due to recent studies describing IL-27 regulation of TIGIT and PD...

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Detalles Bibliográficos
Autores principales: Morrow, Kristen N., Liang, Zhe, Xue, Ming, Chihade, Deena B., Sun, Yini, Chen, Ching-wen, Coopersmith, Craig M., Ford, Mandy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881227/
https://www.ncbi.nlm.nih.gov/pubmed/33615199
http://dx.doi.org/10.1016/j.isci.2021.102093