Alpha-enolase (ENO1), identified as an antigen to monoclonal antibody 12C7, promotes the self-renewal and malignant phenotype of lung cancer stem cells by AMPK/mTOR pathway

BACKGROUND: Tumor-associated antigens (TAAs) can be targeted in cancer therapy. We previously identified a monoclonal antibody (mAb) 12C7, which presented anti-tumor activity in lung cancer stem cells (LCSCs). Here, we aimed to identify the target antigen for 12C7 and confirm its role in LCSCs. METH...

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Detalles Bibliográficos
Autores principales: Shu, Xiong, Cao, Kai-Yue, Liu, Hui-Qi, Yu, Long, Sun, Li-Xin, Yang, Zhi-Hua, Wu, Cheng-Ai, Ran, Yu-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881626/
https://www.ncbi.nlm.nih.gov/pubmed/33579362
http://dx.doi.org/10.1186/s13287-021-02160-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881626/
https://www.ncbi.nlm.nih.gov/pubmed/33579362
http://dx.doi.org/10.1186/s13287-021-02160-9

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