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Alpha-enolase (ENO1), identified as an antigen to monoclonal antibody 12C7, promotes the self-renewal and malignant phenotype of lung cancer stem cells by AMPK/mTOR pathway

BACKGROUND: Tumor-associated antigens (TAAs) can be targeted in cancer therapy. We previously identified a monoclonal antibody (mAb) 12C7, which presented anti-tumor activity in lung cancer stem cells (LCSCs). Here, we aimed to identify the target antigen for 12C7 and confirm its role in LCSCs. METH...

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Detalles Bibliográficos
Autores principales:	Shu, Xiong, Cao, Kai-Yue, Liu, Hui-Qi, Yu, Long, Sun, Li-Xin, Yang, Zhi-Hua, Wu, Cheng-Ai, Ran, Yu-Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881626/ https://www.ncbi.nlm.nih.gov/pubmed/33579362 http://dx.doi.org/10.1186/s13287-021-02160-9

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