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Generation of inner ear sensory neurons using blastocyst complementation in a Neurog1(+/−)−deficient mouse

This research is the first to produce induced pluripotent stem cell-derived inner ear sensory neurons in the Neurog1(+/−) heterozygote mouse using blastocyst complementation. Additionally, this approach corrected non-sensory deficits associated with Neurog1 heterozygosity, indicating that complement...

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Detalles Bibliográficos
Autores principales: Steevens, Aleta R., Griesbach, Matthew W., You, Yun, Dutton, James R., Low, Walter C., Santi, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881691/
https://www.ncbi.nlm.nih.gov/pubmed/33579352
http://dx.doi.org/10.1186/s13287-021-02184-1