Cargando…

A Polygenic Score for Type 2 Diabetes Risk Is Associated With Both the Acute and Sustained Response to Sulfonylureas

There is a limited understanding of how genetic loci associated with glycemic traits and type 2 diabetes (T2D) influence the response to antidiabetic medications. Polygenic scores provide increasing power to detect patterns of disease predisposition that might benefit from a targeted pharmacologic i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Josephine H., Szczerbinski, Lukasz, Dawed, Adem Y., Kaur, Varinderpal, Todd, Jennifer N., Pearson, Ewan R., Florez, Jose C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2021
Materias:	Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881853/ https://www.ncbi.nlm.nih.gov/pubmed/33106254 http://dx.doi.org/10.2337/db20-0530

Ejemplares similares

Genetic Variation at the Sulfonylurea Receptor, Type 2 Diabetes, and Coronary Heart Disease
por: Emdin, Connor A., et al.
Publicado: (2017)

Polygenic Type 2 Diabetes Prediction at the Limit of Common Variant Detection
por: Vassy, Jason L., et al.
Publicado: (2014)

CREBRF missense variant rs373863828 has both direct and indirect effects on type 2 diabetes and fasting glucose in Polynesian peoples living in Samoa and Aotearoa New Zealand
por: Russell, Emily M, et al.
Publicado: (2022)

Pathways Targeted by Antidiabetes Drugs Are Enriched for Multiple Genes Associated With Type 2 Diabetes Risk
por: Segrè, Ayellet V., et al.
Publicado: (2015)

The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium
por: Srinivasan, Shylaja, et al.
Publicado: (2021)

A plasma metabolite score of three eicosanoids predicts incident type 2 diabetes: a prospective study in three independent cohorts
por: Tuomisto, Karolina, et al.
Publicado: (2022)

Metabolite Profiles of Diabetes Incidence and Intervention Response in the Diabetes Prevention Program
por: Walford, Geoffrey A., et al.
Publicado: (2016)

Genetic Loci and Physiologic Pathways Involved in Gestational Diabetes Mellitus Implicated Through Clustering
por: Powe, Camille E., et al.
Publicado: (2021)

Genetic Determinants of Glycemic Traits and the Risk of Gestational Diabetes Mellitus
por: Powe, Camille E., et al.
Publicado: (2018)

Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study
por: Slieker, Roderick C., et al.
Publicado: (2021)

Interaction Between Type 2 Diabetes Prevention Strategies and Genetic Determinants of Coronary Artery Disease on Cardiometabolic Risk Factors
por: Merino, Jordi, et al.
Publicado: (2020)

Novel Human Insulin Isoforms and Cα-Peptide Product in Islets of Langerhans and Choroid Plexus
por: Liu, Qing-Rong, et al.
Publicado: (2021)

Genetic Predisposition to Weight Loss and Regain With Lifestyle Intervention: Analyses From the Diabetes Prevention Program and the Look AHEAD Randomized Controlled Trials
por: Papandonatos, George D., et al.
Publicado: (2015)

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants
por: Wood, Andrew R., et al.
Publicado: (2017)

Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk
por: Marquez, Marcel, et al.
Publicado: (2012)

Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations
por: Chen, Brian H., et al.
Publicado: (2016)

Consistent Directions of Effect for Established Type 2 Diabetes Risk Variants Across Populations: The Population Architecture using Genomics and Epidemiology (PAGE) Consortium
por: Haiman, Christopher A., et al.
Publicado: (2012)

Evidence of Gene-Gene Interaction and Age-at-Diagnosis Effects in Type 1 Diabetes
por: Howson, Joanna M.M., et al.
Publicado: (2012)

Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits
por: Billings, Liana K., et al.
Publicado: (2012)

Association Testing of Previously Reported Variants in a Large Case-Control Meta-analysis of Diabetic Nephropathy
por: Williams, Winfred W., et al.
Publicado: (2012)

A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes
por: Ferreira, Ricardo C., et al.
Publicado: (2014)

No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels
por: Scott, Robert A., et al.
Publicado: (2012)

Genome-Wide Association Study for Type 2 Diabetes in Indians Identifies a New Susceptibility Locus at 2q21
por: Tabassum, Rubina, et al.
Publicado: (2013)

Metabolomic Changes in Serum of Children with Different Clinical Diagnoses of Malnutrition(1)(2)(3)
por: Di Giovanni, Valeria, et al.
Publicado: (2016)

Metabolic Footprinting of Fermented Milk Consumption in Serum of Healthy Men
por: Pimentel, Grégory, et al.
Publicado: (2018)

The Plasma Proteome Is Associated with Anthropometric Status of Undernourished Nepalese School-Aged Children(1)(2)(3)
por: Lee, Sun Eun, et al.
Publicado: (2017)

Identification of Milk and Cheese Intake Biomarkers in Healthy Adults Reveals High Interindividual Variability of Lewis System–Related Oligosaccharides
por: Pimentel, Grégory, et al.
Publicado: (2020)

Treatment with Nitrate, but Not Nitrite, Lowers the Oxygen Cost of Exercise and Decreases Glycolytic Intermediates While Increasing Fatty Acid Metabolites in Exercised Zebrafish
por: Axton, Elizabeth R, et al.
Publicado: (2019)

Personalized Profiling Reveals Donor- and Lactation-Specific Trends in the Human Milk Proteome and Peptidome
por: Zhu, Jing, et al.
Publicado: (2021)

Urine Metabolite Profiles and Nutrient Intake Based on 4-Day Weighed Food Diary in Habitual Vegans, Vegetarians, and Omnivores
por: Lindqvist, Helen M, et al.
Publicado: (2020)

DHA Supplementation Attenuates Inflammation-Associated Gene Expression in the Mammary Gland of Lactating Mothers Who Deliver Preterm
por: Adams, Joselyn M, et al.
Publicado: (2022)

Plasma MicroRNA Signature of Alcohol Consumption: The Rotterdam Study
por: Karabegović, Irma, et al.
Publicado: (2022)

Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity
por: Dimas, Antigone S., et al.
Publicado: (2014)

A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes
por: Mercader, Josep M., et al.
Publicado: (2017)

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
por: Scott, Robert A., et al.
Publicado: (2017)

Deep Resequencing Unveils Genetic Architecture of ADIPOQ and Identifies a Novel Low-Frequency Variant Strongly Associated With Adiponectin Variation
por: Warren, Liling L., et al.
Publicado: (2012)

Peripheral Blood Monocyte Gene Expression Profile Clinically Stratifies Patients With Recent-Onset Type 1 Diabetes
por: Irvine, Katharine M., et al.
Publicado: (2012)

Placental Adiponectin Gene DNA Methylation Levels Are Associated With Mothers’ Blood Glucose Concentration
por: Bouchard, Luigi, et al.
Publicado: (2012)

Hyperglycemia and a Common Variant of GCKR Are Associated With the Levels of Eight Amino Acids in 9,369 Finnish Men
por: Stančáková, Alena, et al.
Publicado: (2012)

A Gene-Family Analysis of 61 Genetic Variants in the Nicotinic Acetylcholine Receptor Genes for Insulin Resistance and Type 2 Diabetes in American Indians
por: Yang, Jingyun, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_2g9bh1psr2n33nqf29oa1ull37