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Developmental malformations in Huntington disease: neuropathologic evidence of focal neuronal migration defects in a subset of adult brains
Neuropathologic hallmarks of Huntington Disease (HD) include the progressive neurodegeneration of the striatum and the presence of Huntingtin (HTT) aggregates that result from abnormal polyQ expansion of the HTT gene. Whether the pathogenic trinucleotide repeat expansion of the HTT gene causes neuro...
Autores principales: | Hickman, R. A., Faust, P. L., Rosenblum, M. K., Marder, K., Mehler, M. F., Vonsattel, J. P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882590/ https://www.ncbi.nlm.nih.gov/pubmed/33517535 http://dx.doi.org/10.1007/s00401-021-02269-4 |
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