Crizotinib and Sunitinib Induce Hepatotoxicity and Mitochondrial Apoptosis in L02 Cells via ROS and Nrf2 Signaling Pathway

Considerable attention has been raised on crizotinib- and sunitinib-induced hepatotoxicity, but the underlying mechanisms need further examination. In addition, limited therapeutic strategies exist to reduce the liver damage caused by crizotinib and sunitinib. This study investigated the mechanisms...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Lin, Gong, Hui, Tang, Ting-Li, Zhang, Bi-Kui, Zhang, Lei-Yi, Yan, Miao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883288/
https://www.ncbi.nlm.nih.gov/pubmed/33597889
http://dx.doi.org/10.3389/fphar.2021.620934

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883288/
https://www.ncbi.nlm.nih.gov/pubmed/33597889
http://dx.doi.org/10.3389/fphar.2021.620934

Ejemplares similares