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Crizotinib and Sunitinib Induce Hepatotoxicity and Mitochondrial Apoptosis in L02 Cells via ROS and Nrf2 Signaling Pathway

Considerable attention has been raised on crizotinib- and sunitinib-induced hepatotoxicity, but the underlying mechanisms need further examination. In addition, limited therapeutic strategies exist to reduce the liver damage caused by crizotinib and sunitinib. This study investigated the mechanisms...

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Detalles Bibliográficos
Autores principales:	Guo, Lin, Gong, Hui, Tang, Ting-Li, Zhang, Bi-Kui, Zhang, Lei-Yi, Yan, Miao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883288/ https://www.ncbi.nlm.nih.gov/pubmed/33597889 http://dx.doi.org/10.3389/fphar.2021.620934

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