Centriolar distal appendages activate the centrosome‐PIDDosome‐p53 signalling axis via ANKRD26

Centrosome amplification results into genetic instability and predisposes cells to neoplastic transformation. Supernumerary centrosomes trigger p53 stabilization dependent on the PIDDosome (a multiprotein complex composed by PIDD1, RAIDD and Caspase‐2), whose activation results in cleavage of p53’s...

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Detalles Bibliográficos
Autores principales: Burigotto, Matteo, Mattivi, Alessia, Migliorati, Daniele, Magnani, Giovanni, Valentini, Chiara, Roccuzzo, Michela, Offterdinger, Martin, Pizzato, Massimo, Schmidt, Alexander, Villunger, Andreas, Maffini, Stefano, Fava, Luca L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883297/
https://www.ncbi.nlm.nih.gov/pubmed/33350486
http://dx.doi.org/10.15252/embj.2020104844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883297/
https://www.ncbi.nlm.nih.gov/pubmed/33350486
http://dx.doi.org/10.15252/embj.2020104844

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