Electrophysiological Abnormalities in VLCAD Deficient hiPSC-Cardiomyocytes Do not Improve with Carnitine Supplementation

Patients with a deficiency in very long-chain acyl-CoA dehydrogenase (VLCAD), an enzyme that is involved in the mitochondrial beta-oxidation of long-chain fatty acids, are at risk for developing cardiac arrhythmias. In human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs), VLCAD def...

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Detalles Bibliográficos
Autores principales: Verkerk, Arie O., Knottnerus, Suzan J. G., Portero, Vincent, Bleeker, Jeannette C., Ferdinandusse, Sacha, Guan, Kaomei, IJlst, Lodewijk, Visser, Gepke, Wanders, Ronald J. A., Wijburg, Frits A., Bezzina, Connie R., Mengarelli, Isabella, Houtkooper, Riekelt H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883678/
https://www.ncbi.nlm.nih.gov/pubmed/33597881
http://dx.doi.org/10.3389/fphar.2020.616834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883678/
https://www.ncbi.nlm.nih.gov/pubmed/33597881
http://dx.doi.org/10.3389/fphar.2020.616834

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