Evolutionary and structural analysis elucidates mutations on SARS-CoV2 spike protein with altered human ACE2 binding affinity

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The recognition of ACE2 by the receptor-binding domain (RBD) of spike protein mediates host cell entry. The objective of the work is to identify SARS-CoV2 spike variants that emerged during the pandemic and evaluate their binding affinity with ACE2. Evolutionary analysis of 2178 SARS-CoV2 genomes id...

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Detalles Bibliográficos
Autor principal: Chakraborty, Sandipan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883683/
https://www.ncbi.nlm.nih.gov/pubmed/33602511
http://dx.doi.org/10.1016/j.bbrc.2021.01.035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883683/
https://www.ncbi.nlm.nih.gov/pubmed/33602511
http://dx.doi.org/10.1016/j.bbrc.2021.01.035

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