Design of genetically encoded sensors to detect nucleosome ubiquitination in live cells

Histone posttranslational modifications (PTMs) are dynamic, context-dependent signals that modulate chromatin structure and function. Ubiquitin (Ub) conjugation to different lysines of histones H2A and H2B is used to regulate diverse processes such as gene silencing, transcriptional elongation, and...

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Detalles Bibliográficos
Autores principales: dos Santos Passos, Carolina, Choi, Yun-Seok, Snow, Christopher D., Yao, Tingting, Cohen, Robert E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883740/
https://www.ncbi.nlm.nih.gov/pubmed/33570569
http://dx.doi.org/10.1083/jcb.201911130