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Epigenetic Regulation of GABAergic Neurotransmission and Neurosteroid Biosynthesis in Alcohol Use Disorder

BACKGROUND: Alcohol use disorder (AUD) is a chronic relapsing brain disorder. GABA(A) receptor (GABA(A)R) subunits are a target for the pharmacological effects of alcohol. Neurosteroids play an important role in the fine-tuning of GABA(A)R function in the brain. Recently, we have shown that AUD is a...

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Detalles Bibliográficos
Autores principales: Gatta, Eleonora, Guidotti, Alessandro, Saudagar, Vikram, Grayson, Dennis R, Aspesi, Dario, Pandey, Subhash C, Pinna, Graziano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883893/
https://www.ncbi.nlm.nih.gov/pubmed/32968808
http://dx.doi.org/10.1093/ijnp/pyaa073