Mechanism of Thimerosal-Induced Structural Destabilization of a Recombinant Rotavirus P[4] Protein Antigen Formulated as a Multi-Dose Vaccine

In a companion paper, a two-step developability assessment is presented to rapidly evaluate low-cost formulations (multi-dose, aluminum-adjuvanted) for new subunit vaccine candidates. As a case study, a non-replicating rotavirus (NRRV) recombinant protein antigen P[4] was found to be destabilized by...

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Detalles Bibliográficos
Autores principales: Kaur, Kawaljit, Xiong, Jian, Sawant, Nishant, Agarwal, Sanjeev, Hickey, John M., Holland, David A., Mukhopadhyay, Tarit K., Brady, Joseph R., Dalvie, Neil C., Tracey, Mary Kate, Love, Kerry R., Love, J. Christopher, Weis, David D., Joshi, Sangeeta B., Volkin, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884053/
https://www.ncbi.nlm.nih.gov/pubmed/33278412
http://dx.doi.org/10.1016/j.xphs.2020.11.033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884053/
https://www.ncbi.nlm.nih.gov/pubmed/33278412
http://dx.doi.org/10.1016/j.xphs.2020.11.033

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