High-throughput behavioral screen in C. elegans reveals Parkinson’s disease drug candidates

We recently linked branched-chain amino acid transferase 1 (BCAT1) dysfunction with the movement disorder Parkinson’s disease (PD), and found that RNAi-mediated knockdown of neuronal bcat-1 in C. elegans causes abnormal spasm-like ‘curling’ behavior with age. Here we report the development of a mach...

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Detalles Bibliográficos
Autores principales: Sohrabi, Salman, Mor, Danielle E., Kaletsky, Rachel, Keyes, William, Murphy, Coleen T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884385/
https://www.ncbi.nlm.nih.gov/pubmed/33589689
http://dx.doi.org/10.1038/s42003-021-01731-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884385/
https://www.ncbi.nlm.nih.gov/pubmed/33589689
http://dx.doi.org/10.1038/s42003-021-01731-z

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