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Inhibition of repulsive guidance molecule-a protects dopaminergic neurons in a mouse model of Parkinson’s disease

Repulsive guidance molecule-a (RGMa), a glycosylphosphatidylinositol-anchored membrane protein, has diverse functions in axon guidance, cell patterning, and cell survival. Inhibition of RGMa attenuates pathological dysfunction in animal models of central nervous system (CNS) diseases including spina...

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Detalles Bibliográficos
Autores principales: Oda, Wakana, Fujita, Yuki, Baba, Kousuke, Mochizuki, Hideki, Niwa, Hitoshi, Yamashita, Toshihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884441/
https://www.ncbi.nlm.nih.gov/pubmed/33589594
http://dx.doi.org/10.1038/s41419-021-03469-2