CBP Bromodomain Inhibition Rescues Mice From Lethal Sepsis Through Blocking HMGB1-Mediated Inflammatory Responses

CREB binding protein (CBP), a transcriptional coactivator and acetyltransferase, is involved in the pathogenesis of inflammation-related diseases. High mobility group box-1 protein (HMGB1) is a critical mediator of lethal sepsis, which has prompted investigation for the development of new treatment...

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Detalles Bibliográficos
Autores principales: Bi, Xiaowen, Jiang, Baolin, Zhou, Jinyi, Fan, Xirui, Yan, Xintong, Liang, Juanjuan, Luo, Lan, Yin, Zhimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884462/
https://www.ncbi.nlm.nih.gov/pubmed/33603756
http://dx.doi.org/10.3389/fimmu.2020.625542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884462/
https://www.ncbi.nlm.nih.gov/pubmed/33603756
http://dx.doi.org/10.3389/fimmu.2020.625542

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