Peroxisomal Multifunctional Protein 2 Deficiency Perturbs Lipid Homeostasis in the Retina and Causes Visual Dysfunction in Mice

Patients lacking multifunctional protein 2 (MFP2), the central enzyme of the peroxisomal β-oxidation pathway, develop retinopathy. This pathway is involved in the metabolism of very long chain (VLCFAs) and polyunsaturated (PUFAs) fatty acids, which are enriched in the photoreceptor outer segments (P...

Descripción completa

Detalles Bibliográficos
Autores principales: Das, Yannick, Swinkels, Daniëlle, Kocherlakota, Sai, Vinckier, Stefan, Vaz, Frédéric M., Wever, Eric, van Kampen, Antoine H. C., Jun, Bokkyoo, Do, Khanh V., Moons, Lieve, Bazan, Nicolas G., Van Veldhoven, Paul P., Baes, Myriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884615/
https://www.ncbi.nlm.nih.gov/pubmed/33604342
http://dx.doi.org/10.3389/fcell.2021.632930

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884615/
https://www.ncbi.nlm.nih.gov/pubmed/33604342
http://dx.doi.org/10.3389/fcell.2021.632930

Ejemplares similares