Cargando…

Single-Cell RNA Sequencing Reveals the Expansion of Cytotoxic CD4(+) T Lymphocytes and a Landscape of Immune Cells in Primary Sjögren’s Syndrome

OBJECTIVE: Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease, and its pathogenetic mechanism is far from being understood. In this study, we aimed to explore the cellular and molecular mechanisms that lead to pathogenesis of this disease. METHODS: We applied single-cell RNA sequencin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hong, Xiaoping, Meng, Shuhui, Tang, Donge, Wang, Tingting, Ding, Liping, Yu, Haiyan, Li, Heng, Liu, Dongzhou, Dai, Yong, Yang, Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884617/ https://www.ncbi.nlm.nih.gov/pubmed/33603736 http://dx.doi.org/10.3389/fimmu.2020.594658

Ejemplares similares

The Chromatin Accessibility Landscape of Peripheral Blood Mononuclear Cells in Patients With Systemic Lupus Erythematosus at Single-Cell Resolution
por: Yu, Haiyan, et al.
Publicado: (2021)

Screening biomarkers for Sjogren’s Syndrome by computer analysis and evaluating the expression correlations with the levels of immune cells
por: Zhong, Yafang, et al.
Publicado: (2023)

Integrated proteome and phosphoproteome analyses of peripheral blood mononuclear cells in primary Sjögren syndrome patients
por: Huang, Shaoying, et al.
Publicado: (2020)

Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Peripheral Mononuclear Cells in Patients With Ankylosing Spondylitis
por: Xu, Huixuan, et al.
Publicado: (2021)

CD8(+) T Lymphocytes: Crucial Players in Sjögren’s Syndrome
por: Zhou, Huimin, et al.
Publicado: (2021)

Coordinated Priming of NKG2D Pathway by IL-15 Enhanced Functional Properties of Cytotoxic CD4(+)CD28(−) T Cells Expanded in Systemic Lupus Erythematosus
por: Wang, Tingting, et al.
Publicado: (2023)

Combined proteomics and single cell RNA-sequencing analysis to identify biomarkers of disease diagnosis and disease exacerbation for systemic lupus erythematosus
por: Li, Yixi, et al.
Publicado: (2022)

Screening Biomarkers for Systemic Lupus Erythematosus Based on Machine Learning and Exploring Their Expression Correlations With the Ratios of Various Immune Cells
por: Zhong, Yafang, et al.
Publicado: (2022)

Microbiome and Metabolome Analyses Reveal the Disruption of Lipid Metabolism in Systemic Lupus Erythematosus
por: He, Jingquan, et al.
Publicado: (2020)

CD8(+) T Lymphocyte and NK Cell Network: Circuitry in the Cytotoxic Domain of Immunity
por: Uzhachenko, Roman V., et al.
Publicado: (2019)

IL-7 Promotes the Expansion of Circulating CD28- Cytotoxic T Lymphocytes in Patients With IgG4-Related Disease via the JAK Signaling
por: Xia, Chang-sheng, et al.
Publicado: (2022)

Degranulation Response in Cytotoxic Rat Lymphocytes Measured with a Novel CD107a Antibody
por: Sudworth, Amanda, et al.
Publicado: (2016)

Absolute quantification and characterization of oxylipins in lupus nephritis and systemic lupus erythematosus
por: He, Jingquan, et al.
Publicado: (2022)

Global Phosphoproteomics Unveils Kinase-Regulated Networks in Systemic Lupus Erythematosus
por: Meng, Shuhui, et al.
Publicado: (2022)

The Era of Cytotoxic CD4 T Cells
por: Cenerenti, Mara, et al.
Publicado: (2022)

IL-27 Regulated CD4(+)IL-10(+) T Cells in Experimental Sjögren Syndrome
por: Qi, Jingjing, et al.
Publicado: (2020)

Landscapes and mechanisms of CD8(+) T cell exhaustion in gastrointestinal cancer
por: Ding, Jia-Tong, et al.
Publicado: (2023)

Selective miRNA inhibition in CD8(+) cytotoxic T lymphocytes enhances HIV-1 specific cytotoxic responses
por: Madrid-Elena, Nadia, et al.
Publicado: (2022)

Single-cell transcriptomics of human gut T cells identifies cytotoxic CD4(+)CD8A(+) T cells related to mouse CD4 cytotoxic T cells
por: Tanemoto, Shun, et al.
Publicado: (2022)

Anaplasma phagocytophilum-Related Defects in CD8, NKT, and NK Lymphocyte Cytotoxicity
por: Scorpio, Diana G., et al.
Publicado: (2018)

Global Proteomic Analyses Reveals Abnormal Immune Regulation in Patients With New Onset Ankylosing Spondylitis
por: Yu, Zongchao, et al.
Publicado: (2022)

Expansions of Cytotoxic CD4(+)CD28(−) T Cells Drive Excess Cardiovascular Mortality in Rheumatoid Arthritis and Other Chronic Inflammatory Conditions and Are Triggered by CMV Infection
por: Broadley, Iain, et al.
Publicado: (2017)

Integrative genomic expression analysis reveals stable differences between lung cancer and systemic sclerosis
por: Li, Heng, et al.
Publicado: (2021)

CD30 Is Dispensable for T-Cell Responses to Influenza Virus and Lymphocytic Choriomeningitis Virus Clone 13 but Contributes to Age-Associated T-Cell Expansion in Mice
por: Zhou, Angela C., et al.
Publicado: (2017)

Gene-regulatory network analysis of ankylosing spondylitis with a single-cell chromatin accessible assay
por: Yu, Haiyan, et al.
Publicado: (2020)

The PD-1/PD-L1 Pathway Affects the Expansion and Function of Cytotoxic CD8(+) T Cells During an Acute Retroviral Infection
por: David, Paul, et al.
Publicado: (2019)

Sequence similarity of SARS-CoV-2 and humans: Implications for SARS-CoV-2 detection
por: Li, Heng, et al.
Publicado: (2022)

Cytotoxic CD4 T cells in the mucosa and in cancer
por: Venkatesh, Hrishi, et al.
Publicado: (2023)

TLR7 agonism accelerates disease in a mouse model of primary Sjögren’s syndrome and drives expansion of T-bet(+) B cells
por: Punnanitinont, Achamaporn, et al.
Publicado: (2022)

Gamma/Delta T Cells in the Course of Healthy Human Pregnancy: Cytotoxic Potential and the Tendency of CD8 Expression Make CD56+ γδT Cells a Unique Lymphocyte Subset
por: Nörenberg, Jasper, et al.
Publicado: (2021)

CD8(+)CD161(+) T-Cells: Cytotoxic Memory Cells With High Therapeutic Potential
por: Konduri, Vanaja, et al.
Publicado: (2021)

The identification of circular RNAs from peripheral blood mononuclear cells in systemic lupus erythematosus
por: Zheng, Fengping, et al.
Publicado: (2021)

Comparison of Phenotypic and Functional Characteristics Between Canine Non-B, Non-T Natural Killer Lymphocytes and CD3(+)CD5(dim)CD21(−) Cytotoxic Large Granular Lymphocytes
por: Lee, Soo-Hyeon, et al.
Publicado: (2018)

High Glucose Enhances Cytotoxic T Lymphocyte-Mediated Cytotoxicity
por: Zhu, Jie, et al.
Publicado: (2021)

CD4(+) T-cell-dependent differentiation of CD23(+) follicular B cells contributes to the pulmonary pathology in a primary Sjögren’s syndrome mouse model
por: Sato-Fukuba, Mami, et al.
Publicado: (2023)

Corrigendum: Gamma/Delta T Cells in the Course of Healthy Human Pregnancy: Cytotoxic Potential and the Tendency of CD8 Expression Make CD56+ γδT Cells a Unique Lymphocyte Subset
por: Nörenberg, Jasper, et al.
Publicado: (2022)

Immune cell and TCR/BCR repertoire profiling in systemic lupus erythematosus patients by single-cell sequencing
por: Zheng, Fengping, et al.
Publicado: (2021)

Editorial: Cytotoxic CD4+ T Cells in Viral Infections
por: Phetsouphanh, Chansavath, et al.
Publicado: (2017)

Differential Requirement of Cd8 Enhancers E8(I) and E8(VI) in Cytotoxic Lineage T Cells and in Intestinal Intraepithelial Lymphocytes
por: Gülich, Alexandra Franziska, et al.
Publicado: (2019)

Integrated analysis of competing endogenous RNA networks in peripheral blood mononuclear cells of systemic lupus erythematosus
por: Song, Wencong, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_97hnj0selp9im6uj3h9qkmtbuf