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Neuroinflammation induces synaptic scaling through IL-1β-mediated activation of the transcriptional repressor REST/NRSF

Neuroinflammation is associated with synapse dysfunction and cognitive decline in patients and animal models. One candidate for translating the inflammatory stress into structural and functional changes in neural networks is the transcriptional repressor RE1-silencing transcription factor (REST) tha...

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Detalles Bibliográficos
Autores principales: Buffolo, Federica, Petrosino, Valentina, Albini, Martina, Moschetta, Matteo, Carlini, Federico, Floss, Thomas, Kerlero de Rosbo, Nicole, Cesca, Fabrizia, Rocchi, Anna, Uccelli, Antonio, Benfenati, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884694/
https://www.ncbi.nlm.nih.gov/pubmed/33589593
http://dx.doi.org/10.1038/s41419-021-03465-6