Practical early cancer detection: distinguishing stable from unstable genomes in pre-cancerous tissues

Barrett’s oesophagus has been known for many years to display early changes to the genome consistent with the risk for oesophageal adenocarcinoma. Recently we have shown that this information can be used without knowledge of individual gene mutations to accurately predict a patient’s future risk of...

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Detalles Bibliográficos
Autores principales: Killcoyne, Sarah, Fitzgerald, Rebecca C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884797/
https://www.ncbi.nlm.nih.gov/pubmed/33154569
http://dx.doi.org/10.1038/s41416-020-01142-7
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author Killcoyne, Sarah
Fitzgerald, Rebecca C.
author_facet Killcoyne, Sarah
Fitzgerald, Rebecca C.
author_sort Killcoyne, Sarah
collection PubMed
description Barrett’s oesophagus has been known for many years to display early changes to the genome consistent with the risk for oesophageal adenocarcinoma. Recently we have shown that this information can be used without knowledge of individual gene mutations to accurately predict a patient’s future risk of malignant progression.
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spelling pubmed-78847972021-03-03 Practical early cancer detection: distinguishing stable from unstable genomes in pre-cancerous tissues Killcoyne, Sarah Fitzgerald, Rebecca C. Br J Cancer Comment Barrett’s oesophagus has been known for many years to display early changes to the genome consistent with the risk for oesophageal adenocarcinoma. Recently we have shown that this information can be used without knowledge of individual gene mutations to accurately predict a patient’s future risk of malignant progression. Nature Publishing Group UK 2020-11-06 2021-02-16 /pmc/articles/PMC7884797/ /pubmed/33154569 http://dx.doi.org/10.1038/s41416-020-01142-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Comment
Killcoyne, Sarah
Fitzgerald, Rebecca C.
Practical early cancer detection: distinguishing stable from unstable genomes in pre-cancerous tissues
title Practical early cancer detection: distinguishing stable from unstable genomes in pre-cancerous tissues
title_full Practical early cancer detection: distinguishing stable from unstable genomes in pre-cancerous tissues
title_fullStr Practical early cancer detection: distinguishing stable from unstable genomes in pre-cancerous tissues
title_full_unstemmed Practical early cancer detection: distinguishing stable from unstable genomes in pre-cancerous tissues
title_short Practical early cancer detection: distinguishing stable from unstable genomes in pre-cancerous tissues
title_sort practical early cancer detection: distinguishing stable from unstable genomes in pre-cancerous tissues
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884797/
https://www.ncbi.nlm.nih.gov/pubmed/33154569
http://dx.doi.org/10.1038/s41416-020-01142-7
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