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Synthesis of trifluoromethyl ketones by nucleophilic trifluoromethylation of esters under a fluoroform/KHMDS/triglyme system
A straightforward method that enables the formation of biologically attractive trifluoromethyl ketones from readily available methyl esters using the potent greenhouse gas fluoroform (HCF(3), HFC-23) was developed. The combination of fluoroform and KHMDS in triglyme at −40 °C was effective for this...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Beilstein-Institut
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884878/ https://www.ncbi.nlm.nih.gov/pubmed/33633811 http://dx.doi.org/10.3762/bjoc.17.39 |