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Synthesis of trifluoromethyl ketones by nucleophilic trifluoromethylation of esters under a fluoroform/KHMDS/triglyme system

A straightforward method that enables the formation of biologically attractive trifluoromethyl ketones from readily available methyl esters using the potent greenhouse gas fluoroform (HCF(3), HFC-23) was developed. The combination of fluoroform and KHMDS in triglyme at −40 °C was effective for this...

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Detalles Bibliográficos
Autores principales:	Fujihira, Yamato, Liang, Yumeng, Ono, Makoto, Hirano, Kazuki, Kagawa, Takumi, Shibata, Norio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2021
Materias:	Letter
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884878/ https://www.ncbi.nlm.nih.gov/pubmed/33633811 http://dx.doi.org/10.3762/bjoc.17.39

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