Prevalence of the Brazilian TP53 Founder c.1010G>A (p.Arg337His) in Lung Adenocarcinoma: Is Genotyping Warranted in All Brazilian Patients?

In Southern and Southeastern Brazil, there is a germline pathogenic variant with incomplete penetrance located in the oligomerization domain of TP53, c.1010G>A (p.Arg337His). Due to a founder effect, the variant is present in 0.3% of the general population of the region. Recently, this variant wa...

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Detalles Bibliográficos
Autores principales: Vieira, Igor Araujo, Andreis, Tiago Finger, Fernandes, Bruna Vieira, Achatz, Maria Isabel, Macedo, Gabriel S., Schramek, Daniel, Ashton-Prolla, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885268/
https://www.ncbi.nlm.nih.gov/pubmed/33603772
http://dx.doi.org/10.3389/fgene.2021.606537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885268/
https://www.ncbi.nlm.nih.gov/pubmed/33603772
http://dx.doi.org/10.3389/fgene.2021.606537

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