Influence of cytochrome P450 (CYP) 2C8 polymorphisms on the efficacy and tolerability of artesunate‐amodiaquine treatment of uncomplicated Plasmodium falciparum malaria in Zanzibar

BACKGROUND: The anti-malarial drug, amodiaquine, a commonly used, long-acting partner drug in artemisinin-based combination therapy, is metabolized to active desethyl-amodiaquine (DEAQ) by cytochrome P450 2C8 (CYP2C8). The CYP2C8 gene carries several polymorphisms including the more frequent minor a...

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Detalles Bibliográficos
Autores principales: Pernaute-Lau, Leyre, Morris, Ulrika, Msellem, Mwinyi, Mårtensson, Andreas, Björkman, Anders, Gil, Jose Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885591/
https://www.ncbi.nlm.nih.gov/pubmed/33588856
http://dx.doi.org/10.1186/s12936-021-03620-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885591/
https://www.ncbi.nlm.nih.gov/pubmed/33588856
http://dx.doi.org/10.1186/s12936-021-03620-6

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