Redesigning the Molecular Choreography to Prevent Hydroxylation in Germacradien-11-ol Synthase Catalysis

[Image: see text] Natural sesquiterpene synthases have evolved to make complex terpenoids by quenching reactive carbocations either by proton transfer or by hydroxylation (water capture), depending on their active site. Germacradien-11-ol synthase (Gd11olS) from Streptomyces coelicolor catalyzes the...

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Detalles Bibliográficos
Autores principales: Srivastava, Prabhakar L., Escorcia, Andrés M., Huynh, Florence, Miller, David J., Allemann, Rudolf K., van der Kamp, Marc W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886051/
https://www.ncbi.nlm.nih.gov/pubmed/33614194
http://dx.doi.org/10.1021/acscatal.0c04647

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886051/
https://www.ncbi.nlm.nih.gov/pubmed/33614194
http://dx.doi.org/10.1021/acscatal.0c04647

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