A redox-active crosslinker reveals an essential and inhibitable oxidative folding network in the endoplasmic reticulum of malaria parasites

Malaria remains a major global health problem, creating a constant need for research to identify druggable weaknesses in P. falciparum biology. As important components of cellular redox biology, members of the Thioredoxin (Trx) superfamily of proteins have received interest as potential drug targets...

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Detalles Bibliográficos
Autores principales: Cobb, David W., Kudyba, Heather M., Villegas, Alejandra, Hoopmann, Michael R., Baptista, Rodrigo P., Bruton, Baylee, Krakowiak, Michelle, Moritz, Robert L., Muralidharan, Vasant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886143/
https://www.ncbi.nlm.nih.gov/pubmed/33534803
http://dx.doi.org/10.1371/journal.ppat.1009293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886143/
https://www.ncbi.nlm.nih.gov/pubmed/33534803
http://dx.doi.org/10.1371/journal.ppat.1009293

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