Identification of ligand-specific G protein-coupled receptor states and prediction of downstream efficacy via data-driven modeling

Ligand binding stabilizes different G protein-coupled receptor states via a complex allosteric process that is not completely understood. Here, we have derived free energy landscapes describing activation of the β(2) adrenergic receptor bound to ligands with different efficacy profiles using enhance...

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Detalles Bibliográficos
Autores principales: Fleetwood, Oliver, Carlsson, Jens, Delemotte, Lucie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886328/
https://www.ncbi.nlm.nih.gov/pubmed/33506760
http://dx.doi.org/10.7554/eLife.60715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886328/
https://www.ncbi.nlm.nih.gov/pubmed/33506760
http://dx.doi.org/10.7554/eLife.60715

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