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Characterization and Validation of Arg286 Residue of IL-1RAcP as a Potential Drug Target for Osteoarthritis

Osteoarthritis (OA) is the most common form of arthritis and the fastest growing cause of chronic disability in the world. Formation of the ternary IL-1β /IL-1R1/IL-1RAcP protein complex and its downstream signaling has been implicated in osteoarthritis pathology. Current OA therapeutic approaches t...

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Detalles Bibliográficos
Autores principales:	Dailing, Angela, Mitchell, Kelsey, Vuong, Ngoc, Lee, Kyung Hyeon, Joshi, Reva, Espina, Virginia, Haymond Still, Amanda, Gottschalk, Carter J., Brown, Anne M., Paige, Mikell, Liotta, Lance A., Luchini, Alessandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886681/ https://www.ncbi.nlm.nih.gov/pubmed/33614593 http://dx.doi.org/10.3389/fchem.2020.601477

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