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Auxin-mediated protein depletion for metabolic engineering in terpene-producing yeast

In metabolic engineering, loss-of-function experiments are used to understand and optimise metabolism. A conditional gene inactivation tool is required when gene deletion is lethal or detrimental to growth. Here, we exploit auxin-inducible protein degradation as a metabolic engineering approach in y...

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Detalles Bibliográficos
Autores principales: Lu, Zeyu, Peng, Bingyin, Ebert, Birgitta E., Dumsday, Geoff, Vickers, Claudia E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886869/
https://www.ncbi.nlm.nih.gov/pubmed/33594068
http://dx.doi.org/10.1038/s41467-021-21313-1