A high-throughput Galectin-9 imaging assay for quantifying nanoparticle uptake, endosomal escape and functional RNA delivery

RNA-based therapies have great potential to treat many undruggable human diseases. However, their efficacy, in particular for mRNA, remains hampered by poor cellular delivery and limited endosomal escape. Development and optimisation of delivery vectors, such as lipid nanoparticles (LNPs), are imped...

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Detalles Bibliográficos
Autores principales: Munson, Michael J., O’Driscoll, Gwen, Silva, Andreia M., Lázaro-Ibáñez, Elisa, Gallud, Audrey, Wilson, John T., Collén, Anna, Esbjörner, Elin K., Sabirsh, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887203/
https://www.ncbi.nlm.nih.gov/pubmed/33594247
http://dx.doi.org/10.1038/s42003-021-01728-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887203/
https://www.ncbi.nlm.nih.gov/pubmed/33594247
http://dx.doi.org/10.1038/s42003-021-01728-8

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