G-quadruplex binding properties of a potent PARP-1 inhibitor derived from 7-azaindole-1-carboxamide

Poly ADP-ribose polymerases (PARP) are key proteins involved in DNA repair, maintenance as well as regulation of programmed cell death. For this reason they are important therapeutic targets for cancer treatment. Recent studies have revealed a close interplay between PARP1 recruitment and G-quadrupl...

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Detalles Bibliográficos
Autores principales: Dallavalle, Sabrina, Musso, Loana, Artali, Roberto, Aviñó, Anna, Scaglioni, Leonardo, Eritja, Ramon, Gargallo, Raimundo, Mazzini, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887208/
https://www.ncbi.nlm.nih.gov/pubmed/33594142
http://dx.doi.org/10.1038/s41598-021-83474-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887208/
https://www.ncbi.nlm.nih.gov/pubmed/33594142
http://dx.doi.org/10.1038/s41598-021-83474-9

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