RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation

mTORC1, a central controller of cell proliferation in response to growth factors and nutrients, is dysregulated in cancer. Whereas arginine activates mTORC1, it is overridden by high expression of cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1). Because cancer cells often encounter low leve...

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Detalles Bibliográficos
Autores principales: Li, Tingting, Wang, Xian, Ju, Enguo, da Silva, Suzane Ramos, Chen, Luping, Zhang, Xinquan, Wei, Shan, Gao, Shou-Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887217/
https://www.ncbi.nlm.nih.gov/pubmed/33594058
http://dx.doi.org/10.1038/s41467-021-21206-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887217/
https://www.ncbi.nlm.nih.gov/pubmed/33594058
http://dx.doi.org/10.1038/s41467-021-21206-3

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