Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides

In the cell, DNA is arranged into highly-organised and topologically-constrained (supercoiled) structures. It remains unclear how this supercoiling affects the detailed double-helical structure of DNA, largely because of limitations in spatial resolution of the available biophysical tools. Here, we...

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Detalles Bibliográficos
Autores principales: Pyne, Alice L. B., Noy, Agnes, Main, Kavit H. S., Velasco-Berrelleza, Victor, Piperakis, Michael M., Mitchenall, Lesley A., Cugliandolo, Fiorella M., Beton, Joseph G., Stevenson, Clare E. M., Hoogenboom, Bart W., Bates, Andrew D., Maxwell, Anthony, Harris, Sarah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887228/
https://www.ncbi.nlm.nih.gov/pubmed/33594049
http://dx.doi.org/10.1038/s41467-021-21243-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887228/
https://www.ncbi.nlm.nih.gov/pubmed/33594049
http://dx.doi.org/10.1038/s41467-021-21243-y

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