Therapeutic depletion of CCR8(+) tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy

BACKGROUND: Modulation and depletion strategies of regulatory T cells (Tregs) constitute valid approaches in antitumor immunotherapy but suffer from severe adverse effects due to their lack of selectivity for the tumor-infiltrating (ti-)Treg population, indicating the need for a ti-Treg specific bio...

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Detalles Bibliográficos
Autores principales: Van Damme, Helena, Dombrecht, Bruno, Kiss, Máté, Roose, Heleen, Allen, Elizabeth, Van Overmeire, Eva, Kancheva, Daliya, Martens, Liesbet, Murgaski, Aleksandar, Bardet, Pauline Madeleine Rachel, Blancke, Gillian, Jans, Maude, Bolli, Evangelia, Martins, Maria Solange, Elkrim, Yvon, Dooley, James, Boon, Louis, Schwarze, Julia Katharina, Tacke, Frank, Movahedi, Kiavash, Vandamme, Niels, Neyns, Bart, Ocak, Sebahat, Scheyltjens, Isabelle, Vereecke, Lars, Nana, Frank Aboubakar, Merchiers, Pascal, Laoui, Damya, Van Ginderachter, Jo Agnes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Immunotherapy Biomarkers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887378/
https://www.ncbi.nlm.nih.gov/pubmed/33589525
http://dx.doi.org/10.1136/jitc-2020-001749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887378/
https://www.ncbi.nlm.nih.gov/pubmed/33589525
http://dx.doi.org/10.1136/jitc-2020-001749

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