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Tamoxifen feeding method is suitable for efficient conditional knockout

The Cre-driver system is used to generate conditional knockout mice. Tamoxifen inducible Cre-driver mice can be used for spatiotemporal knockout by administration of the drug. A major tamoxifen administration is performed by intraperitoneal administration or oral administration. However, these force...

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Detalles Bibliográficos
Autores principales: Yoshinobu, Kumiko, Araki, Masatake, Morita, Ayaka, Araki, Miyuki, Kokuba, Shun, Nakagata, Naomi, Araki, Kimi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Association for Laboratory Animal Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887626/
https://www.ncbi.nlm.nih.gov/pubmed/33055491
http://dx.doi.org/10.1538/expanim.19-0138