Cargando…
A Machine Learning Strategy for Drug Discovery Identifies Anti-Schistosomal Small Molecules
[Image: see text] Schistosomiasis is a chronic and painful disease of poverty caused by the flatworm parasite Schistosoma. Drug discovery for antischistosomal compounds predominantly employs in vitro whole organism (phenotypic) screens against two developmental stages of Schistosoma mansoni, post-in...
Autores principales: | Zorn, Kimberley M., Sun, Shengxi, McConnon, Cecelia L., Ma, Kelley, Chen, Eric K., Foil, Daniel H., Lane, Thomas R., Liu, Lawrence J., El-Sakkary, Nelly, Skinner, Danielle E., Ekins, Sean, Caffrey, Conor R. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2021
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887754/ https://www.ncbi.nlm.nih.gov/pubmed/33434015 http://dx.doi.org/10.1021/acsinfecdis.0c00754 |
Ejemplares similares
-
Octopamine signaling in the metazoan pathogen Schistosoma mansoni: localization, small-molecule screening and opportunities for drug development
por: El-Sakkary, Nelly, et al.
Publicado: (2018) -
Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation
por: Padalino, Gilda, et al.
Publicado: (2021) -
A secreted schistosome cathepsin B1 cysteine protease and acute schistosome infection induce a transient T helper 17 response
por: Soloviova, Kateryna, et al.
Publicado: (2019) -
Machine Learning for Discovery of GSK3β Inhibitors
por: Vignaux, Patricia A., et al.
Publicado: (2020) -
Bioactivity of Farnesyltransferase Inhibitors Against Entamoeba histolytica and Schistosoma mansoni
por: Probst, Alexandra, et al.
Publicado: (2019)