17β-Estradiol Induces Mitophagy Upregulation to Protect Chondrocytes via the SIRT1-Mediated AMPK/mTOR Signaling Pathway

Increasing evidence reveals that estrogen, especially 17β-estradiol (17β-E2), is associated with articular cartilage metabolism disorder and postmenopausal osteoarthritis (OA). SIRT1, AMPK, and mTOR are regarded as critical mitophagy regulators. Recent studies have shown that mitophagy displays a pr...

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Detalles Bibliográficos
Autores principales: Mei, Runhong, Lou, Peng, You, Guanchao, Jiang, Tianlong, Yu, Xuefeng, Guo, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888342/
https://www.ncbi.nlm.nih.gov/pubmed/33613450
http://dx.doi.org/10.3389/fendo.2020.615250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888342/
https://www.ncbi.nlm.nih.gov/pubmed/33613450
http://dx.doi.org/10.3389/fendo.2020.615250

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