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17β-Estradiol Induces Mitophagy Upregulation to Protect Chondrocytes via the SIRT1-Mediated AMPK/mTOR Signaling Pathway

Increasing evidence reveals that estrogen, especially 17β-estradiol (17β-E2), is associated with articular cartilage metabolism disorder and postmenopausal osteoarthritis (OA). SIRT1, AMPK, and mTOR are regarded as critical mitophagy regulators. Recent studies have shown that mitophagy displays a pr...

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Detalles Bibliográficos
Autores principales:	Mei, Runhong, Lou, Peng, You, Guanchao, Jiang, Tianlong, Yu, Xuefeng, Guo, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888342/ https://www.ncbi.nlm.nih.gov/pubmed/33613450 http://dx.doi.org/10.3389/fendo.2020.615250

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