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TRPM4 mediates a subthreshold membrane potential oscillation in respiratory chemoreceptor neurons that drives pacemaker firing and breathing

Brainstem networks that control regular tidal breathing depend on excitatory drive, including from tonically active, CO(2)/H(+)-sensitive neurons of the retrotrapezoid nucleus (RTN). Here, we examine intrinsic ionic mechanisms underlying the metronomic firing activity characteristic of RTN neurons....

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Detalles Bibliográficos
Autores principales: Li, Keyong, Abbott, Stephen B.G., Shi, Yingtang, Eggan, Pierce, Gonye, Elizabeth C., Bayliss, Douglas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888550/
https://www.ncbi.nlm.nih.gov/pubmed/33535052
http://dx.doi.org/10.1016/j.celrep.2021.108714