Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles

Abnormal protein aggregation within neurons is a key pathologic feature of Parkinson’s disease (PD). The spread of brain protein aggregates is associated with clinical disease progression, but how this occurs remains unclear. Mutations in glucosidase, beta acid 1 (GBA), which encodes glucocerebrosid...

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Detalles Bibliográficos
Autores principales: Jewett, Kathryn A., Thomas, Ruth E., Phan, Chi Q., Lin, Bernice, Milstein, Gillian, Yu, Selina, Bettcher, Lisa F., Neto, Fausto Carnevale, Djukovic, Danijel, Raftery, Daniel, Pallanck, Leo J., Davis, Marie Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888665/
https://www.ncbi.nlm.nih.gov/pubmed/33539341
http://dx.doi.org/10.1371/journal.pgen.1008859

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888665/
https://www.ncbi.nlm.nih.gov/pubmed/33539341
http://dx.doi.org/10.1371/journal.pgen.1008859

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