TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy

Mislocalization of the TAR DNA-binding protein 43 (TDP-43; encoded by TARDBP) from the nucleus to the cytoplasm is a common feature of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). The downstream in vivo cellular effects of thi...

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Detalles Bibliográficos
Autores principales: Atkinson, Rachel, Leung, Jacqueline, Bender, James, Kirkcaldie, Matthew, Vickers, James, King, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888715/
https://www.ncbi.nlm.nih.gov/pubmed/33408125
http://dx.doi.org/10.1242/dmm.047548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888715/
https://www.ncbi.nlm.nih.gov/pubmed/33408125
http://dx.doi.org/10.1242/dmm.047548

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