Repression of Wnt/β-catenin signaling by SOX9 and Mastermind-like transcriptional coactivator 2

Wnt/β-catenin signaling requires inhibition of a multiprotein destruction complex that targets β-catenin for proteasomal degradation. SOX9 is a potent antagonist of the Wnt pathway and has been proposed to act through direct binding to β-catenin or the β-catenin destruction complex. Here, we demonst...

Descripción completa

Detalles Bibliográficos
Autores principales: Sinha, Abhishek, Fan, Vinson B., Ramakrishnan, Aravinda-Bharathi, Engelhardt, Nicole, Kennell, Jennifer, Cadigan, Ken M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888933/
https://www.ncbi.nlm.nih.gov/pubmed/33597243
http://dx.doi.org/10.1126/sciadv.abe0849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888933/
https://www.ncbi.nlm.nih.gov/pubmed/33597243
http://dx.doi.org/10.1126/sciadv.abe0849

Ejemplares similares