Cargando…

Repression of Wnt/β-catenin signaling by SOX9 and Mastermind-like transcriptional coactivator 2

Wnt/β-catenin signaling requires inhibition of a multiprotein destruction complex that targets β-catenin for proteasomal degradation. SOX9 is a potent antagonist of the Wnt pathway and has been proposed to act through direct binding to β-catenin or the β-catenin destruction complex. Here, we demonst...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sinha, Abhishek, Fan, Vinson B., Ramakrishnan, Aravinda-Bharathi, Engelhardt, Nicole, Kennell, Jennifer, Cadigan, Ken M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888933/ https://www.ncbi.nlm.nih.gov/pubmed/33597243 http://dx.doi.org/10.1126/sciadv.abe0849

Ejemplares similares

SOX9 and TCF transcription factors associate to mediate Wnt/β-catenin target gene activation in colorectal cancer
por: Ramakrishnan, Aravinda-Bharathi, et al.
Publicado: (2022)

Wnt target genes and where to find them
por: Ramakrishnan, Aravinda-Bharathi, et al.
Publicado: (2017)

Diffusion and function of Wnt ligands
por: Stewart, Richard A., et al.
Publicado: (2019)

Wnt target enhancer regulation by a CDX/TCF transcription factor collective and a novel DNA motif
por: Ramakrishnan, Aravinda-Bharathi, et al.
Publicado: (2021)

Structure-Function Analysis of the C-clamp of TCF/Pangolin in Wnt/ß-catenin Signaling
por: Ravindranath, Aditi, et al.
Publicado: (2014)

Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5
por: Hattori, Takako, et al.
Publicado: (2008)

Midsummer mysteries: Criminal masterminds? Not really…
por: Antonella Del Rosso
Publicado: (2014)

SOX9 is an atypical intestinal tumor suppressor controlling the oncogenic Wnt/ß-catenin signaling
por: Prévostel, Corinne, et al.
Publicado: (2016)

Wnt-Mediated Repression via Bipartite DNA Recognition by TCF in the Drosophila Hematopoietic System
por: Zhang, Chen U., et al.
Publicado: (2014)

Selective Phenotyping, Entropy Reduction, and the Mastermind game
por: Gagneur, Julien, et al.
Publicado: (2011)

Felix Berezin: Life and death of the mastermind of supermathematics
por: Shifman, M, et al.
Publicado: (2007)

Bicyclic β‐Sheet Mimetics that Target the Transcriptional Coactivator β‐Catenin and Inhibit Wnt Signaling
por: Wendt, Mathias, et al.
Publicado: (2021)

BCL9, a coactivator for Wnt/β-catenin transcription, is targeted by miR-30c and is associated with prostate cancer progression
por: LING, XIAO-HUI, et al.
Publicado: (2016)

Masterminds of programming: conversations with the creators of major programming languages
por: Biancuzzi, Federico, et al.
Publicado: (2009)

Securing Office 365: masterminding MDM and compliance in the cloud
por: Katzer, Matthew
Publicado: (2018)

Interplay Between SOX9, Wnt/β-Catenin and Androgen Receptor Signaling in Castration-Resistant Prostate Cancer
por: Khurana, Namrata, et al.
Publicado: (2019)

Effect of inhibition of CBP-coactivated β-catenin-mediated Wnt signalling in uremic rats with vascular calcifications
por: Gravesen, Eva, et al.
Publicado: (2018)

The Transcriptional Coactivator Cbp Interacts with β-Catenin to Activate Gene Expression
por: Takemaru, Ken-Ichi, et al.
Publicado: (2000)

SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes
por: Blache, Philippe, et al.
Publicado: (2004)

Sox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/β-catenin signaling
por: Leung, Carmen Oi-Ning, et al.
Publicado: (2016)

Nuclear receptor/Wnt beta-catenin interactions are regulated via differential CBP/p300 coactivator usage
por: Ono, Masaya, et al.
Publicado: (2018)

Mastermind-Like 1 Is Ubiquitinated: Functional Consequences for Notch Signaling
por: Farshbaf, Mozhgan, et al.
Publicado: (2015)

SOX9 drives the epithelial–mesenchymal transition in non-small-cell lung cancer through the Wnt/β-catenin pathway
por: Huang, Jing-Qiang, et al.
Publicado: (2019)

Claudin-7 deficiency promotes stemness properties in colorectal cancer through Sox9-mediated Wnt/β-catenin signalling
por: Xu, Chang, et al.
Publicado: (2021)

A SOX9‐AS1/miR‐5590‐3p/SOX9 positive feedback loop drives tumor growth and metastasis in hepatocellular carcinoma through the Wnt/β‐catenin pathway
por: Zhang, Wei, et al.
Publicado: (2019)

Using the Game of Mastermind to Teach, Practice, and Discuss Scientific Reasoning Skills
por: Strom, Amy R., et al.
Publicado: (2011)

mastermind regulates niche ageing independently of the Notch pathway in the Drosophila ovary
por: Lobo-Pecellín, María, et al.
Publicado: (2019)

α-Catenin interacts with APC to regulate β-catenin proteolysis and transcriptional repression of Wnt target genes
por: Choi, Seung H., et al.
Publicado: (2013)

Sox9 represses gene expression via histone deacetylase activity
por: Tsuda, M, et al.
Publicado: (2003)

SOX4 regulates invasion of bladder cancer cells via repression of WNT5a
por: Moran, Josue D., et al.
Publicado: (2019)

Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network
por: Mukherjee, Shreyasi, et al.
Publicado: (2020)

Repression of Wnt/β-catenin response elements by p63 (TP63)
por: Katoh, Iyoko, et al.
Publicado: (2016)

The Role of the C-Clamp in Wnt-Related Colorectal Cancers
por: Ravindranath, Aditi J., et al.
Publicado: (2016)

Online Mastermind Groups: A Non-hierarchical Mentorship Model for Professional Development
por: Paetow, Glenn, et al.
Publicado: (2018)

Risk of Anemia With Metformin Use in Type 2 Diabetes: A MASTERMIND Study
por: Donnelly, Louise A., et al.
Publicado: (2020)

Innate Immunity in Diabetic Wound Healing: Focus on the Mastermind Hidden in Chronic Inflammatory
por: Geng, Kang, et al.
Publicado: (2021)

SOX30, a target gene of miR-653-5p, represses the proliferation and invasion of prostate cancer cells through inhibition of Wnt/β-catenin signaling
por: Fu, Qiang, et al.
Publicado: (2019)

Odd‐skipped related 1 inhibits lung cancer proliferation and invasion by reducing Wnt signaling through the suppression of SOX9 and β‐catenin
por: Wang, Yuan, et al.
Publicado: (2018)

Maternal Wnt/β-Catenin Signaling Coactivates Transcription through NF-κB Binding Sites during Xenopus Axis Formation
por: Armstrong, Neil J., et al.
Publicado: (2012)

The dyskerin ribonucleoprotein complex as an OCT4/SOX2 coactivator in embryonic stem cells
por: Fong, Yick W, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_9km3u76knqf1cql55f3nv1fo2t