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3D microscopy and deep learning reveal the heterogeneity of crown-like structure microenvironments in intact adipose tissue

Crown-like structures (CLSs) are adipose microenvironments of macrophages engulfing adipocytes. Their histological density in visceral adipose tissue (VAT) predicts metabolic disorder progression in obesity and is believed to initiate obesity comorbidities. Here, we use three-dimensional (3D) light...

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Detalles Bibliográficos
Autores principales: Geng, Junlong, Zhang, Xiaohui, Prabhu, Suma, Shahoei, Sayyed Hamed, Nelson, Erik R., Swanson, Kelly S., Anastasio, Mark A., Smith, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888944/
https://www.ncbi.nlm.nih.gov/pubmed/33597245
http://dx.doi.org/10.1126/sciadv.abe2480